SIMULTANEOUS ASSAY OF ARIPIPRAZOLE AND ITS ACTIVE METABOLITE IN SERUM BY HPLC.
Dorota MarszalekAnna GoldnikTomasz PawinskiGrzegorz MalekAleksander SomogiAnna MachPublished in: Acta poloniae pharmaceutica (2018)
A rapid, convenient, precise HPLC method was developed for the simultaneous determination of aripiprazole and its active metabolite dehydroaripiprazole in blood serum. The separation was carried out by RP HPLC on Symmetry C₁₈ column (150 x 4.6 mm; 5 μm). The mobile phase was composed of acetonitrile: water (30 : 70, v/v), pH 3.0 adjusted with o-phosphoric acid. The detection was monitored at 220 nm.
Keyphrases
- simultaneous determination
- liquid chromatography
- liquid chromatography tandem mass spectrometry
- tandem mass spectrometry
- solid phase extraction
- high performance liquid chromatography
- ultra high performance liquid chromatography
- mass spectrometry
- loop mediated isothermal amplification
- high resolution mass spectrometry
- ms ms
- high throughput
- photodynamic therapy
- gas chromatography
- sensitive detection