Modification of the Association Between Frequent Aspirin Use and Ovarian Cancer Risk: A Meta-Analysis Using Individual-Level Data From Two Ovarian Cancer Consortia.
Lauren M HurwitzMary K TownsendSusan J JordanAlpa V PatelLauren R TerasJames V LaceyJennifer Anne DohertyHolly R HarrisMarc T GoodmanYurii B ShvetsovFrancesmary ModugnoKirsten B MoysichKim RobienAnna PrizmentJoellen M SchildkrautAndrew BerchuckRenée Turzanski FortnerAndrew T ChanNicolas WenstzensenPatricia HartgeDale R SandlerKatie M O'BrienHoda Anton-CulverArgyrios ZiogasUsha MenonSusan J RamusCeleste Leigh PearceAnna H WuEmily WhiteUlrike PetersPenelope M WebbShelley T TworogerBritton TrabertPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)
This study, the largest to-date on aspirin use and ovarian cancer, provides evidence that frequent aspirin use is associated with lower ovarian cancer risk regardless of the presence of most other ovarian cancer risk factors. Risk reductions were also observed among women with multiple risk factors, providing proof of principle that chemoprevention programs with frequent aspirin use could target higher-risk subgroups.