Effects of RORγt overexpression on the murine central nervous system.

Tetsuya SasakiRei NagataSatoru Takahashi Yosuke Takei

Published in: Neuropsychopharmacology reports (2021)

Our findings indicate that a continuous increase of IL-17A in response to RORγt overexpression resulted in decreased microglia activity in the dentate gyrus, but had only a subtle effect on murine hippocampal functions.

Keyphrases

cell proliferation
transcription factor
inflammatory response
neuropathic pain
cerebrospinal fluid
cerebral ischemia
spinal cord
blood brain barrier