Soluble CD163 and soluble mannose receptor predict survival and decompensation in patients with liver cirrhosis, and correlate with gut permeability and bacterial translocation.

Florian RainerA HorvathT D SandahlB LeberB SchmerboeckA BleslA Groselj-StreleR E StauberP FickertP StieglerH J MøllerH GrønbaekV Stadlbauer

Published in: Alimentary pharmacology & therapeutics (2017)

Our data demonstrate the prognostic value of sCD163 in predicting long-term survival in patients with liver cirrhosis and identify soluble mannose receptor as a prognostic marker for occurrence of cirrhosis-associated complications. The correlation between gut barrier dysfunction and activation of macrophages points towards a link between them.

Keyphrases

risk assessment
oxidative stress
electronic health record
endothelial cells
big data
binding protein
machine learning