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SGLT2 Inhibition by Dapagliflozin Attenuates Diabetic Ketoacidosis in Mice with Type-1 Diabetes.

Huan ChenYochai BirnbaumRegina YeHsiu-Chiung YangMandeep BajajYumei Ye
Published in: Cardiovascular drugs and therapy (2021)
Dapagliflozin reduced ketone body levels and attenuated the activation of NFκB and the activation of the inflammasome in T1DM mice with ketoacidosis.
Keyphrases
  • high fat diet induced
  • signaling pathway
  • type diabetes
  • lps induced
  • wild type
  • nuclear factor
  • skeletal muscle
  • wound healing
  • inflammatory response
  • toll like receptor