[Russian experience in using a combination of fixed doses of donepezil and memantine in the treatment of Alzheimer's disease as an observational non-interventional multicenter program].

I V Kolykhalov E A Mhitaryan Ya B Fedorova E V Ponomareva N D Selezneva M A Cherdak N G Dudchenko A B Seyfedinova R I Isaev Svetlana I Gavrilova Olga N Tkacheva

Published in: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2023)

Fixed-dose combination therapy with Mioreol is an effective and well-tolerated treatment option for patients with moderate-to-severe AD. A combination of fixed-dose therapeutic doses of donepezil and memantine is potentially more appropriate than the simultaneous use of two recommended drugs for the treatment of AD, which will improve treatment adherence in patients with moderate to severe AD.

Keyphrases

combination therapy
clinical trial
early onset
cognitive decline
skeletal muscle
glycemic control