Antimicrobial activity of silver sulfide quantum dots functionalized with highly conjugated Schiff bases in a one-step synthesis.

In the present paper, low-dimensional Ag 2 S QDs were fabricated for the first time, with four different dithiocarbazate derivative Schiff bases (SB) as capping agents in a one-pot synthesis. These SB-capped Ag 2 S QDs were almost spherical with an average size range of 4.0 to 5.6 nm, which is slightly smaller than conventional thioglycolic acid (TGA)-capped Ag 2 S QDs. We demonstrate that the growth of Gram-positive bacteria ( Bacillus subtillus and Staphylococcus aureus ), Gram-negative bacteria ( Escherichia coli and Pseudomonas aeruginosa ), and a prevalent fungal pathogen ( Candida albicans ) are inhibited more when the bacterial and fungal cells were nurtured with the synthesized SB-Ag 2 S QDs, compared with TGA-Ag 2 S QDs or free unbound Schiff bases. The minimum inhibitory concentration (MIC) results confirmed that even low concentrations of SB-Ag 2 S QDs were able to inhibit bacterial (MIC 5-75 μg mL -1 ) and fungal growth (MIC 80-310 μg mL -1 ), and in some cases they performed better than streptomycin (8-25 μg mL -1 ). Lethality bioassay results confirmed that SB-Ag 2 S QDs were not toxic to brine shrimp ( Artemia salina ). The results show that capping agents are essential in the design of functional Ag 2 S QDs, and highlight that Schiff bases provide an excellent opportunity to optimize the biological activities of silver based QDs.