Schwann cell transient receptor potential ankyrin 1 (TRPA1) ortholog in zebrafish larvae mediates chemotherapy-induced peripheral neuropathy.

Elisa BellantoniMatilde MariniMartina ChiecaChiara GabelliniErica Lucia CrapanzanoDaniel Souza Monteiro de AraujoDaniele NosiLorenzo RoschiLorenzo Landini Gaetano De Siena Pasquale PensieriAlessandra MastricciIrene ScuffiPierangelo Geppetti Romina Nassini Francesco De Logu

Published in: British journal of pharmacology (2024)

These results indicate that the contribution of the oxidative stress/Schwann cell/TRPA1 pro-allodynic pathway to neuropathic pain models seems to be conserved across the animal kingdom.

Keyphrases

neuropathic pain
oxidative stress
single cell
chemotherapy induced
spinal cord
spinal cord injury
cell therapy
peripheral nerve
transcription factor
dna damage
stem cells
ischemia reperfusion injury
human health
signaling pathway
blood brain barrier
drosophila melanogaster