Simple and robust polymer-based sensor for rapid cancer detection using serum.
Ngoc D B LeArvind K SinglaYingying GengJinsong HanKai SeehaferGyan PrakashDaniel F MoyanoCharlene M DowneyMichael J MonumentDoha ItaniUwe H F BunzFrank R JirikVincent M RotelloPublished in: Chemical communications (Cambridge, England) (2019)
We report a polymer-based sensor that rapidly detects cancer based on changes in serum protein levels. Using three ratiometric fluorescence outputs, this simple system identifies early stage and metastatic lung cancer with a high level of accuracy exceeding many biomarker-based assays, making it an attractive strategy for point-of-care testing.
Keyphrases
- papillary thyroid
- early stage
- squamous cell
- squamous cell carcinoma
- loop mediated isothermal amplification
- small cell lung cancer
- high throughput
- sensitive detection
- quantum dots
- lymph node metastasis
- energy transfer
- gene expression
- fluorescent probe
- radiation therapy
- dna methylation
- small molecule
- single cell
- sentinel lymph node
- rectal cancer