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FGFR3 overexpression is a useful detection tool for FGFR3 fusions and sequence variations in glioma.

Cornelia BrendleLukas ZieglerJan SperveslageMichel MittelbronnDavid CapperIsabel BurghardtAntti PosoSaskia BiskupMarco SkardellyGhazaleh Tabatabai
Published in: Neuro-oncology practice (2020)
FGFR3 IHC is a useful screening tool for the detection of FGFR3 alterations and could be included in the workflow for isocitrate dehydrogenase (IDH) wild-type glioma diagnostics. Samples with positive FGFR3 staining could then be selected for NGS-based diagnostic tools.
Keyphrases
  • wild type
  • loop mediated isothermal amplification
  • label free
  • real time pcr
  • quantum dots
  • flow cytometry