FGFR3 overexpression is a useful detection tool for FGFR3 fusions and sequence variations in glioma.

Cornelia BrendleLukas ZieglerJan SperveslageMichel MittelbronnDavid CapperIsabel BurghardtAntti PosoSaskia BiskupMarco SkardellyGhazaleh Tabatabai

Published in: Neuro-oncology practice (2020)

FGFR3 IHC is a useful screening tool for the detection of FGFR3 alterations and could be included in the workflow for isocitrate dehydrogenase (IDH) wild-type glioma diagnostics. Samples with positive FGFR3 staining could then be selected for NGS-based diagnostic tools.

Keyphrases

wild type
loop mediated isothermal amplification
label free
real time pcr
quantum dots
flow cytometry