KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer Activation and BET Inhibitor Sensitivity.

Yulong Qiang Jiachen Fan Chuanshuai Xie Leilei Yan Xiaofei Song Nan Zhang Yan Lin Jie Xiong Wei Zhang Yu Liu Lei Wei Yu Li Shizhen Chen Kai-Wei Liang Feng Li

Published in: Cancer research (2024)

BRD4 is recruited to enhancers in a bromodomain-independent manner by binding KDM5C and stimulates KDM5C H3K4 demethylase activity, leading to synergistic effects of BET and KDM5C inhibitor combinations in cancer.

Keyphrases

transcription factor
papillary thyroid
gene expression
binding protein
genome wide
squamous cell carcinoma
cancer therapy
drug delivery
lymph node metastasis