CD44 regulates Epac1-mediated β-adrenergic-receptor-induced Ca 2+ -handling abnormalities: implication in cardiac arrhythmias.

Yi-Hsin ChanFeng-Chun TsaiGwo-Jyh ChangYing-Ju LaiShang-Hung ChangWei-Jan ChenYung-Hsin Yeh

Published in: Journal of biomedical science (2023)

-handling abnormalities and VAs. Inhibition of CD44 is effective in reducing VAs in HF, which is potentially a novel therapeutic target for preventing the arrhythmias and sudden cardiac death in patients with diseased hearts.

Keyphrases

congenital heart disease
high glucose
nk cells
left ventricular
diabetic rats
oxidative stress
drug induced