Illuminating cytochrome P450 binding: Ru(ii)-caged inhibitors of CYP17A1.

Ao LiRahul YadavJessica K WhiteMackenzie K HerroonBrian P CallahanIzabela PodgorskiClaudia TurroEmily E ScottJeremy J Kodanko

Published in: Chemical communications (Cambridge, England) (2018)

New Ru(ii)-caged abiraterone complexes were synthesized that exhibit strong absorption in the visible region and release the steroidal CYP17A1 inhibitor abiraterone upon exposure to low energy visible light in buffer and prostate cancer cells. Photoinduced release results in abiraterone binding to its CYP17A1 target in an inhibitory mode.

Keyphrases

visible light
energy transfer
dna binding
electron transfer
transcription factor