PD-1 Targeted Nanoparticles Inhibit Activated T Cells and Alleviate Autoimmunity via Suppression of Cellular Energy Metabolism Mediated by PKM2.

Zhangluxi LiuJing XuHongxi LiJia ShuGuannan SuChunjiang ZhouPeizeng Yang

Published in: International journal of nanomedicine (2022)

The novel nanoplatform TPP could suppress Th1 and Th17 cells and exhibited an anti-inflammatory effect on EAU, providing an alternative approach to ameliorate autoimmune diseases mediated by these cells.

Keyphrases

induced apoptosis
cell cycle arrest
anti inflammatory
cancer therapy
endoplasmic reticulum stress
photodynamic therapy
oxidative stress
cell proliferation