Effects of Gallic Acid on Endometrial Cancer Cells in Two and Three Dimensional Cell Culture Models.

Muhammet Volkan Bulbul Seda Karabulut Mervenur Kalender Ilknur Keskin

Published in: Asian Pacific journal of cancer prevention : APJCP (2021)

Gallic Acid is shown to induce apoptosis in Ishikawa cells via Caspase 3 activation. We demonstrated a significantly higher IC50 level in 3D model which provide evidence to prefer 3D models in drug-test trials. The data obtained in the current study will provide a basis for further experiments to analyze the effects of GA on endometrial cancer and to develop strategies for clinical treatment.

Keyphrases

endometrial cancer
cell cycle arrest
induced apoptosis
cell death
endoplasmic reticulum stress
oxidative stress
pi k akt
signaling pathway
electronic health record
emergency department
cell proliferation
drug induced