Cognitive function in patients with stable coronary heart disease: Related cerebrovascular and cardiovascular responses.
Mathieu GaydaVincent GremeauxLouis BhererMartin JuneauJoffrey DrignyOlivier DupuyGabriel LapierreVéronique LabelleAnnik FortierAnil NigamPublished in: PloS one (2017)
Chronic exercise has been shown to prevent or slow age-related decline in cognitive functions in otherwise healthy, asymptomatic individuals. We sought to assess cognitive function in a stable coronary heart disease (CHD) sample and its relationship to cerebral oxygenation-perfusion, cardiac hemodynamic responses, and [Formula: see text] peak compared to age-matched and young healthy control subjects. Twenty-two young healthy controls (YHC), 20 age-matched old healthy controls (OHC) and 25 patients with stable CHD were recruited. Cognitive function assessment included short term-working memory, perceptual abilities, processing speed, cognitive inhibition and flexibility and long-term verbal memory. Maximal cardiopulmonary function (gas exchange analysis), cardiac hemodynamic (impedance cardiography) and left frontal cerebral oxygenation-perfusion (near-infra red spectroscopy) were measured during and after a maximal incremental ergocycle test. Compared to OHC and CHD, YHC had higher [Formula: see text] peak, maximal cardiac index (CI max), cerebral oxygenation-perfusion (ΔO2 Hb, ΔtHb: exercise and recovery) and cognitive function (for all items) (P<0.05). Compared to OHC, CHD patients had lower [Formula: see text] peak, CI max, cerebral oxygenation-perfusion (during recovery) and short term-working memory, processing speed, cognitive inhibition and flexibility and long-term verbal memory (P<0.05). [Formula: see text] peak and CI max were related to exercise cerebral oxygenation-perfusion and cognitive function (P<0.005). Cerebral oxygenation-perfusion (exercise) was related to cognitive function (P<0.005). Stable CHD patients have a worse cognitive function, a similar cerebral oxygenation/perfusion during exercise but reduced one during recovery vs. their aged-matched healthy counterparts. In the all sample, cognitive functions correlated with [Formula: see text] peak, CI max and cerebral oxygenation-perfusion.
Keyphrases
- working memory
- subarachnoid hemorrhage
- resistance training
- contrast enhanced
- high intensity
- transcranial direct current stimulation
- end stage renal disease
- attention deficit hyperactivity disorder
- blood flow
- physical activity
- cerebral ischemia
- chronic kidney disease
- smoking cessation
- brain injury
- newly diagnosed
- ejection fraction
- left ventricular
- magnetic resonance imaging
- prognostic factors
- human milk
- heart rate
- patient reported outcomes
- computed tomography
- heart failure
- magnetic resonance
- atrial fibrillation
- middle aged
- mass spectrometry