Urethral luminal epithelia are castration-insensitive cells of the proximal prostate.

Diya B JosephGervaise H HenryAlicia MalewskaNida S IqbalHannah M RuettenAnne E TurcoLisa L AblerSimran K SandhuMark T CadenaVenkat S MalladiJeffrey C ReeseRyan J MauckJeffrey C GahanRyan C HutchinsonClaus G RoehrbornLinda A BakerChad M Vezina Douglas W Strand

Published in: The Prostate (2020)

Our data demonstrate that cells of the proximal prostate that express putative progenitor markers, and are enriched by castration in the proximal prostate, are urethral luminal cells and that these cells may play an important role in the etiology of human BPH.

Keyphrases

induced apoptosis
prostate cancer
cell cycle arrest
endoplasmic reticulum stress
benign prostatic hyperplasia
endothelial cells
signaling pathway
artificial intelligence
deep learning
data analysis