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A practical preparation of bicyclic boronates via metal-free heteroatom-directed alkenyl sp 2 -C‒H borylation.

Pei-Ying PengGui-Shan ZhangMei-Ling GongJian-Wei ZhangXi-Liang LiuDingding GaoGuo-Qiang LinQing-Hua LiPing Tian
Published in: Communications chemistry (2023)
Bicyclic boronates play critical roles in the discovery of functional materials and antibacterial agents, especially against deadly bacterial pathogens. Their practical and convenient preparation is in high demand but with great challenge. Herein, we report an efficient strategy for the preparation of bicyclic boronates through metal-free heteroatom-directed alkenyl sp 2 -C‒H borylation. This synthetic approach exhibits good functional group compatibility, and the corresponding boronates bearing halides, aryls, acyclic and cyclic frameworks are obtained with high yields (43 examples, up to 95% yield). Furthermore, a gram-scale experiment is conducted, and downstream transformations of the bicyclic boronates are pursued to afford natural products, drug scaffolds, and chiral hemiboronic acid catalysts.
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