Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis.
Laurienne EdgarNaveed AkbarAdam T BraithwaiteThomas KrausgruberHéctor Gallart-AyalaJade BaileyAlastair L CorbinTariq E KhoyrattyJoshua T ChaiMohammad AlkhalilAndré Figueiredo RendeiroKlemen ZibernaRitu AryaThomas J CahillChristoph BockJurga LaurencikieneMark J CrabtreeMadeleine E LemieuxNiels P RiksenMihai G NeteaCraig E WheelockKeith M ChannonMikael RydénIrina A UdalovaRicardo Carnicer HijazoRobin P ChoudhuryPublished in: Circulation (2021)
Hyperglycemia-induced trained immunity may explain why targeting elevated glucose is ineffective in reducing macrovascular risk in diabetes and suggests new targets for disease prevention and therapy.