The Antitumor Effect of Topotecan Loaded Thiolated Chitosan-Dextran Nanoparticles for Intravitreal Chemotherapy: A Xenograft Retinoblastoma Model.

Leila AghajanpourMahmoud JabbarvandFariba GhassemiFahimeh Asadi AmoliFatemeh AtyabiSaeed Heidari KeshelAlireza LashayFarnaz Sadat Mirzazadeh TekieMasoud SoleimaniRassoul Dinarvand

Published in: Journal of ophthalmic & vision research (2023)

This investigation revealed definitive antitumor efficacy of TPH-CMD-TCS-NPs by intravitreal administration in the rabbit xenograft retinoblastoma model.

Keyphrases

drug delivery
vascular endothelial growth factor
diabetic retinopathy
locally advanced
age related macular degeneration
squamous cell carcinoma
single cell
cancer therapy
radiation therapy
endothelial cells
hyaluronic acid
chemotherapy induced