LncRNA like NMRK2 mRNA functions as a key molecular scaffold to enhance mitochondrial respiration of NONO-TFE3 rearranged renal cell carcinoma in an NAD + kinase-independent manner.

Yi ChenYanwen LuLei YangWenliang MaYuhan DongShuoming ZhouNing LiuWeidong GanDongmei Li

Published in: Journal of experimental & clinical cancer research : CR (2023)

Overall, our data comprehensively demonstrated the mechanisms for the enhanced mitochondrial respiration in NONO-TFE3 rRCC and proposed lncRNA like NMRK2 mRNA as a therapy target for NONO-TFE3 rRCC.

Keyphrases

renal cell carcinoma
oxidative stress
long non coding rna
binding protein
long noncoding rna
electronic health record
big data
tyrosine kinase
single molecule
bone marrow