Peripheral blood cellular immunophenotype in depression: a systematic review and meta-analysis.

Éimear M FoleyJoel T ParkinsonRuth E MitchellLorinda TurnerGolam M Khandaker

Published in: Molecular psychiatry (2022)

Depression is characterised by widespread alterations in circulating myeloid and lymphoid cells, consistent with dysfunction in both innate and adaptive immunity. Immune cells could be useful biomarkers for illness subtyping and patient stratification in future immunotherapy trials of depression, along with cytokines, other biomarkers, and clinical measures.

Keyphrases

depressive symptoms
peripheral blood
sleep quality
immune response
induced apoptosis
bone marrow
acute myeloid leukemia
cell cycle arrest
cell death
physical activity
cell proliferation