Diagnostic work-up and therapeutic implications in MINOCA: need for a personalized approach.
Marco Giuseppe Del BuonoRocco Antonio MontoneGiulia IannacconeMaria Chiara MeucciRiccardo RinaldiDomenico D'AmarioGiampaolo NiccoliPublished in: Future cardiology (2020)
Myocardial infarction with non-obstructive coronary artery (MINOCA) disease represents a heterogeneous clinical conundrum accounting for about 6% of all acute myocardial infarction (MI) cases. Initially believed to be a benign condition, is now becoming clear that MINOCA is associated with a non-negligible risk of mortality, rehospitalization, disability and angina burden at follow-up, with high socioeconomic costs. To date, there are no prospective clinical trials in this population and cannot be assumed that benefits observed in patients suffering from MI with obstructive coronary artery disease may successfully translate to this syndrome. Herein, we comment on the importance of the multimodality assessment to properly identify and treat the specific causes of MINOCA, in order to improve prognosis and the quality of life in these patients.
Keyphrases
- coronary artery
- coronary artery disease
- end stage renal disease
- acute myocardial infarction
- clinical trial
- chronic kidney disease
- newly diagnosed
- percutaneous coronary intervention
- ejection fraction
- prognostic factors
- multiple sclerosis
- left ventricular
- heart failure
- pulmonary artery
- cardiovascular events
- patient reported outcomes
- acute coronary syndrome
- coronary artery bypass grafting
- risk factors
- pulmonary arterial hypertension
- case report
- pulmonary hypertension