KRS: A cut away from release in exosomes.

Published in: The Journal of cell biology (2017)

Cancer cells often trigger an inflammatory process, which in some cases may be driven by the presence of lysyl-tRNA synthetase (KRS) in the medium. Kim et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605118) now demonstrate that cleavage of the KRS by caspase-8 inside cells triggers its interaction with syntenin and its release in inflammatory exosomes.

Keyphrases

induced apoptosis
oxidative stress
mesenchymal stem cells
stem cells
endoplasmic reticulum stress
cell therapy
signaling pathway
single cell
cell death
dna binding
bone marrow
cell proliferation