TBAI/TBHP-Mediated Cascade Cyclization toward Sulfonylated Indeno[1,2-c]quinolines.
Jatuporn MeesinManat PohmakotrVichai ReutrakulDarunee SoorukramPawaret LeowanawatSaowanit SaithongChutima KuhakarnPublished in: Organic letters (2017)
Treatment of ortho-amino-substituted aryldiyne derivatives with sulfonyl hydrazides in the presence of tetrabutylammonium iodide (TBAI) and tert-butyl hydroperoxide (TBHP) led to a cascade cyclization reaction to yield sulfonylated indeno[1,2-c]quinolines in moderate to good yields. The features of the methodology include metal-free reaction, the ease of reagent handling, and a broad functional group tolerance.
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