Methylated DNA Markers for Sporadic Colorectal and Endometrial Cancer Are Strongly Associated with Lynch Syndrome Cancers.
Rachel M BrambletJamie Nadine Bakkum-GamezSeth W SlettedahlPatrick H FooteWilliam R TaylorCalise K BergerBrianna J GysbersJacquelyn ArndtLongwen ChenKaren A DoeringKelli N BurgerDouglas W MahoneyMark E ShermanJohn B KisielN Jewel SamadderPublished in: Cancer prevention research (Philadelphia, Pa.) (2023)
Lynch syndrome (LS) markedly increases risks of colorectal and endometrial cancers. Early detection biomarkers for LS cancers could reduce the needs for invasive screening and surgery. Methylated DNA markers previously identified in sporadic endometrial cancer and colorectal cancer discriminate between benign and cancer tissue in LS.
Keyphrases
- endometrial cancer
- circulating tumor
- cell free
- late onset
- single molecule
- minimally invasive
- papillary thyroid
- case report
- amyotrophic lateral sclerosis
- childhood cancer
- nucleic acid
- squamous cell carcinoma
- coronary artery disease
- acute coronary syndrome
- climate change
- circulating tumor cells
- percutaneous coronary intervention