A Review on The Pathogenesis of Cardiovascular Disease of Flaviviridea Viruses Infection.
Tie-Hua YangWen-Cong GaoXin MaQian LiuPan-Pan PangYong-Tang ZhengYinnong JiaChang-Bo ZhengPublished in: Viruses (2024)
Members of the Flaviviridae family, encompassing the Flavivirus and Hepacivirus genera, are implicated in a spectrum of severe human pathologies. These diseases span a diverse spectrum, including hepatitis, vascular shock syndrome, encephalitis, acute flaccid paralysis, and adverse fetal outcomes, such as congenital heart defects and increased mortality rates. Notably, infections by Flaviviridae viruses have been associated with substantial cardiovascular compromise, yet the exploration into the attendant cardiovascular sequelae and underlying mechanisms remains relatively underexplored. This review aims to explore the epidemiology of Flaviviridae virus infections and synthesize their cardiovascular morbidities. Leveraging current research trajectories and our investigative contributions, we aspire to construct a cogent theoretical framework elucidating the pathogenesis of Flaviviridae -induced cardiovascular injury and illuminate prospective therapeutic avenues.
Keyphrases
- cardiovascular disease
- endothelial cells
- drug induced
- type diabetes
- risk factors
- cardiovascular events
- emergency department
- early onset
- respiratory failure
- metabolic syndrome
- coronary artery disease
- mechanical ventilation
- induced pluripotent stem cells
- cardiovascular risk factors
- acute respiratory distress syndrome