Innate immune responses are increased in children with acute asthma exacerbation.
Shahid I SheikhMariah EisnerJoshua WalumKathryn HeyobAiman Q KhanBrandon LewisMitchell GraysonBenjamin KoppKaren McCoyRodney D BrittPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2024)
In acute asthma exacerbation, innate immune pathways remained increased while adaptive immune responses related to T helper cells are blunted and are independent of trigger or asthma severity. Our novel findings highlight the need to identify new therapies to target persistent innate immune responses to improve outcomes in acute asthma.
Keyphrases
- chronic obstructive pulmonary disease
- innate immune
- immune response
- lung function
- liver failure
- respiratory failure
- allergic rhinitis
- dendritic cells
- drug induced
- induced apoptosis
- toll like receptor
- type diabetes
- adipose tissue
- oxidative stress
- hepatitis b virus
- endoplasmic reticulum stress
- skeletal muscle
- weight loss