αB-Crystallin Peptide Fused with Elastin-like Polypeptide: Intracellular Activity in Retinal Pigment Epithelial Cells Challenged with Oxidative Stress.

Sara Aly AttiaAnh Tan TruongAlvin PhanShin-Jae LeeManal AbanmaiMarinella MarkanovicHugo AvilaHaozhong LuoAtham AliParameswaran Gangadharan SreekumarRam KannanJohn Andrew MacKay

Published in: Antioxidants (Basel, Switzerland) (2023)

ELP architecture is a critical factor to optimize delivery of therapeutic peptides, such as the anti-apoptotic mini-cry peptide; furthermore, the protection of mini-cry via ELPs is enhanced by lysosomal membrane permeabilization.

Keyphrases

oxidative stress
cell death
ischemia reperfusion injury
anti inflammatory
signaling pathway