HGF and IL-10 expressing ALB::GFP reporter cells generated from iPSCs show robust anti-fibrotic property in acute fibrotic liver model.
Ja Sung ChoiIn Sil JeongYoung-Jin ParkSung-Whan KimPublished in: Stem cell research & therapy (2020)
This study has investigated and proven the liver regeneration potential of genome-edited iHep cells and promises to be a strong foundation for further studies exploring cell therapy as an alternative therapeutic option for the treatment of liver fibrosis.
Keyphrases
- cell therapy
- induced apoptosis
- liver fibrosis
- cell cycle arrest
- stem cells
- crispr cas
- systemic sclerosis
- idiopathic pulmonary fibrosis
- endoplasmic reticulum stress
- mesenchymal stem cells
- signaling pathway
- cell death
- gene expression
- genome wide
- dna methylation
- mass spectrometry
- cell proliferation
- replacement therapy
- acute respiratory distress syndrome