CEACAM1 marks highly suppressive intratumoral regulatory T cells for targeted depletion therapy.

Seung Hyuck Jeon Minyong Kang Minwoo Jeon You-Seung Chung A Reum Kim Yong Joon Lee Eui-Soon Kim Heejin Nam Jung-Yun Lee Jung-Yun Lee Eui-Cheol Shin Seong Il Seo Su-Hyung Park

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

CEACAM1 marks highly suppressive subset of intratumoral Tregs, and can be a target for selective depletion of intratumoral Tregs. These results may inform future studies on CEACAM1-mediated depletion in cancer patients.

Keyphrases

regulatory t cells
dendritic cells
cancer therapy
current status
stem cells
immune response
mesenchymal stem cells
replacement therapy
smoking cessation