Epigenetic age and pregnancy outcomes: GrimAge acceleration is associated with shorter gestational length and lower birthweight.

Kharah M RossJudith E CarrollSteve HorvathCalvin J HobelMary E Coussons-ReadChristine Dunkel Schetter

Published in: Clinical epigenetics (2020)

Higher maternal prenatal GrimAgeAccel, DNAm PAI-1, DNAm ADM, and DNAm cystatin C were associated with shorter gestational length and lower birthweight. These findings suggest that biological age, as measured by these epigenetic indices, could indicate risk for adverse pregnancy outcomes.

Keyphrases

pregnancy outcomes
pregnant women
nk cells
dna methylation
gene expression
gestational age
weight gain
emergency department
physical activity