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Cell Sequence and Mitosis Affect Fibroblast Directional Decision-Making During Chemotaxis in Microfluidic Mazes.

Quang Long PhamLydia N RodriguesMax A MaximovVishnu Deep ChandranCheng BiDavid ChegeTimothy DijamcoElisabeth SteinNhat Anh Nguyen TongSagnik BasurayRoman S Voronov
Published in: Cellular and molecular bioengineering (2018)
It is apparent that micro-confined fibroblasts modify each other's directional decisions in a manner that is counter-intuitive to what is expected from classical chemotaxis theory. Consequently, accounting for these effects could lead to a better understanding of tissue generation in vivo, and result in more advanced engineered tissue products in vitro.
Keyphrases
  • single cell
  • decision making
  • cell therapy
  • circulating tumor cells
  • magnetic resonance
  • bone marrow
  • label free