Epigenetic age acceleration, fatigue, and inflammation in patients undergoing radiation therapy for head and neck cancer: A longitudinal study.

Canhua XiaoJonathan J BeitlerGang PengMorgan E LevineKaren N ConneelyHongyu ZhaoJennifer C FelgerEvanthia C WommackCynthia E ChicoSangchoon JeonKristin A HigginsDong M ShinNabil F SabaBarbara A BurtnessDeborah W BrunerAndrew H Miller

Published in: Cancer (2021)

Patients with head and neck cancer experienced increased EAA, especially immediately after treatment completion. EAA was associated with greater fatigue and inflammation, including 1 year after treatment. Inflammation may be a target to reduce the impact of age acceleration on poor functional outcomes.

Keyphrases

oxidative stress
patients undergoing
gene expression
dna methylation
sleep quality