Synthesis and photochemical properties of caged peroxides for photocontrol of cellular oxidative stress.

Mieko TsujiHaruno TairaTaro UdagawaTatsuya AokiTasuku Hirayama Hideko Nagasawa

Published in: Chemical communications (Cambridge, England) (2023)

We developed a caged hydroperoxide, BhcTBHP, releasing prooxidant TBHP under blue light irradiation. MitoTBHP with triphenylphosphonium at position 7 triggered selective oxidative stress and membrane depolarization in mitochondria upon photoirradiation. This study presents a powerful tool for studying redox signaling and oxidative stress in living cells.

Keyphrases

oxidative stress
living cells
dna damage
diabetic rats
fluorescent probe
ischemia reperfusion injury
induced apoptosis
single molecule
cell death
radiation therapy
heat stress
electron transfer