Predictors of subclinical systemic sclerosis primary heart involvement characterised by microvasculopathy and myocardial fibrosis.
Raluca B DumitruLesley-Anne BissellBara ErhayiemGraham FentAnanth KidambiPeter SwobodaGiuseppina AbignanoHelena DonicaAgata BurskaJohn P GreenwoodJohn BiglandsFrancesco Del GaldoSven PleinMaya H BuchPublished in: Rheumatology (Oxford, England) (2021)
Subclinical SSc-pHI is characterized by myocardial microvasculopathy, diffuse and focal myocardial fibrosis but preserved myocardial contractile function. This subclinical phenotype of SSc-pHI was associated with high-sensitivity troponin I, N-terminal pro-brain natriuretic peptide, SSc disease severity and complicated peripheral vasculopathy. These data provide information regarding the underlying pathophysiological processes and provide a basis for identifying individuals at risk of SSc-pHI.
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