Genome-Wide Association Studies of Cognitive and Motor Progression in Parkinson's Disease.
Manuela M X TanMichael A LawtonEdwin JabbariRegina H ReynoldsHirotaka IwakiCornelis BlauwendraatSofia KanavouMiriam I PollardLeon HubbardNaveed MalekKatherine A GrossetSarah L MarrinanNin BajajRoger A BarkerDavid J BurnCatherine BresnerThomas FoltynieNicholas W WoodCaroline H Williams-GrayJohn HardyMichael A NallsAndrew B SingletonNigel M WilliamsYoav Ben-ShlomoMichele T M HuDonald G GrossetMaryam ShoaiHuw R MorrisPublished in: Movement disorders : official journal of the Movement Disorder Society (2020)
We provide early evidence that this new method in PD improves measurement of symptom progression. We show that the APOE ε4 allele drives progressive cognitive impairment in PD. Replication of this method and results in independent cohorts are needed. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.