89Zr-pembrolizumab biodistribution is influenced by PD-1-mediated uptake in lymphoid organs.
Elly L van der VeenDanique GiesenLinda Pot-de JongAnnelies Jorritsma-SmitElisabeth G E De VriesMarjolijn N Lub-de HoogePublished in: Journal for immunotherapy of cancer (2021)
89Zr-pembrolizumab whole-body biodistribution showed high PD-1-mediated uptake in lymphoid tissues, such as spleen, lymph nodes and bone marrow, and modest tumor uptake. Our data may enable evaluation of 89Zr-pembrolizumab whole-body distribution in patients.
Keyphrases
- pet imaging
- bone marrow
- lymph node
- advanced non small cell lung cancer
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- gene expression
- mesenchymal stem cells
- prognostic factors
- positron emission tomography
- patient reported outcomes
- neoadjuvant chemotherapy
- machine learning
- deep learning
- data analysis