Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis.
Síle F MolloyBrad RossCecilia KanyamaSayoki MfinangaSokoine LesikariRobert Simon HeydermanNewton KalataJayne P EllisCharles KouanfackDuncan ChandaElvis TemfackShabir LakhiAnand MoodleyAdrienne K ChanJoep J van OosterhoutYacouba MapourePeter MwabaDavid G LallooDuolao WangOlivier LortholaryShabbar JaffarMina C HosseinipourAngela LoyseThomas S HarrisonTihana BicanicPublished in: Open forum infectious diseases (2021)
Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH2O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36-4.83; P = .02) and fungal burden >6.0 log10 colonies/mL (aOR, 3.01; 95% CI, 1.58-5.7; P = .003) were independently associated with severe visual loss.