Identification of homozygous haplotypes carrying putative recessive lethal mutations that compromise fertility traits in French Lacaune dairy sheep.

Maxime Ben Braiek Stéphane FabreChris HozéJean-Michel AstrucCarole R Moreno

Published in: Genetics, selection, evolution : GSE (2021)

Based on a reverse genetic strategy, we identified at least 11 haplotypes with homozygous deficiency segregating in French Lacaune dairy sheep. This strategy represents a first tool to limit at-risk matings in the Lacaune dairy selection scheme. We assume that most of the identified LDHH are in strong linkage disequilibrium with a recessive lethal mutation that affects embryonic or juvenile survival in sheep but is yet to be identified.

Keyphrases

genome wide
intellectual disability
gene expression
copy number
bioinformatics analysis