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Cryostorage of unstable N -acetylglucosaminyltransferase-V by synthetic zwitterions.

Tetsuya HirataTakahiro TakekiyoYukihiro YoshimuraYuko TokoroTakeru IshizakiYasuhiko KizukaKosuke Kuroda
Published in: RSC advances (2022)
We report biocompatible materials for cryostorage of unstable proteins such as cancer-related enzyme, N -acetylglucosaminyltransferase-V (GnT-V). GnT-V activity and the amount of protein after freezing were better retained in synthetic zwitterion solutions than in the glycerol solution. This study highlights the potential utility of synthetic zwitterions as novel cryoprotectants.
Keyphrases
  • protein protein
  • risk assessment
  • amino acid
  • drug delivery
  • small molecule
  • climate change
  • solid state