Vascular mechanisms of post-COVID-19 conditions: rho-kinase is a novel target for therapy.

Robert A Sykes Karla Bianca NevesRhéure Alves-LopesIlaria CaputoKirsty FallonNigel B Jamieson Anna Kamdar Assya LegriniHolly LeslieAlasdair McIntosh Alexander McConnachie Andrew J Morrow Richard W McFarlane Kenneth MangionJohn McAbneyAugusto C Montezano Rhian M TouyzColin WoodColin Berry

Published in: European heart journal. Cardiovascular pharmacotherapy (2023)

Patients with post-COVID-19 conditions have enhanced vascular fibrosis and myosin light change phosphorylation. Rho-kinase activation represents a novel therapeutic target for clinical trials.

Keyphrases

protein kinase
coronavirus disease
sars cov
clinical trial
tyrosine kinase
stem cells
phase iii