Mismatch Repair (MMR) Gene Alteration and BRAF V600E Mutation Are Potential Predictive Biomarkers of Immune Checkpoint Inhibitors in MMR-Deficient Colorectal Cancer.

Ibrahim Halil SahinSubir GoyalYoanna PumpalovaMohamad B SonbolSatya DasSigurdis HaraldsdottirDaniel AhnKristen K CiomborZhengjia ChenAmber DraperJordan BerlinTanios Bekaii-SaabGregory B LesinskiBassel F El-RayesChristina Wu

Published in: The oncologist (2021)

The results of this study reveal clinically important biomarkers that potentially predict immune checkpoint inhibitor response in patients with mismatch repair-deficient colorectal cancer.

Keyphrases

genome wide
wild type
copy number
single cell
dna methylation
human health
transcription factor
climate change
genome wide identification