Extracellular Vesicles Involvement in the Modulation of the Glioblastoma Environment.
Fausta CiccocioppoPaola LanutiMarco MarchisioSebastiano MisciaPublished in: Journal of oncology (2020)
Glioblastoma (GBM) is the most deadly primary brain tumour and is a paradigmatic example of heterogeneous cancer. Although expanding data propose the phenotypic plasticity exhibited by glioblastoma cells, as a critical feature involved in the tumour development and posttherapy recurrence, the central machinery responsible for their aggressiveness remains elusive. Despite decades of research, the complex biology of the glioblastoma is still unknown. Progress in genetic and epigenetic discoveries has improved diagnostic classification, prognostic information, and therapeutic planning. In the complex model of intercellular signalling, several studies have shown that extracellular vesicles have a key role in the intercellular communication among GBM cells and the tumour microenvironment modulation. The purpose of this review is to summarize the role of the EV-mediated intercellular crosstalk in the glioblastoma physiopathology.
Keyphrases
- induced apoptosis
- cell cycle arrest
- machine learning
- deep learning
- cell adhesion
- stem cells
- dna methylation
- squamous cell carcinoma
- endoplasmic reticulum stress
- blood brain barrier
- young adults
- cell death
- multiple sclerosis
- social media
- health information
- resting state
- functional connectivity
- cerebral ischemia
- data analysis
- neural network