High-parameter cytometry unmasks microglial cell spatio-temporal response kinetics in severe neuroinflammatory disease.

Alanna G SpiteriRachel L TerryClaire L WishartThomas M AshhurstIain L CampbellMarkus J HoferNicholas Jonathan Cole King

Published in: Journal of neuroinflammation (2021)

Our approach enables detailed kinetic analysis of resident vs infiltrating myeloid cells in a wide range of neuroinflammatory models without non-physiological manipulation. This will more clearly inform potential therapeutic approaches that specifically modulate these cells.

Keyphrases

induced apoptosis
cell cycle arrest
single cell
inflammatory response
bone marrow
oxidative stress
patient safety
cell death
signaling pathway
stem cells
early onset
lipopolysaccharide induced
neuropathic pain
cell proliferation
quality improvement
spinal cord