Impact of individual level uncertainty of lung cancer polygenic risk score (PRS) on risk stratification.
Xinan WangZiwei ZhangYi DingTony ChenLorelei MucciDemetrios AlbanesMaria Teresa LandiNeil E CaporasoStephen LamAdonina TardonChu ChenStig E BojesenMattias JohanssonAngela RischHeike BickeböllerH-Erich WichmannGadi RennertSusanne ArnoldPaul BrennanJames D McKayJohn K FieldSanjay S SheteLoic Le MarchandGeoffrey LiuAngeline S AndrewLambertus A KiemeneyShan Zienolddiny-NaruiAnnelie BehndigMikael JohanssonAngie CoxPhilip LazarusMatthew B SchabathMelinda C AldrichRayjean J HungChristopher I AmosXihong LinDavid Chistopher ChristianiPublished in: Genome medicine (2024)
Lung cancer PRS estimates using different methods have modest correlations at the individual level, highlighting the importance of considering individual-level uncertainty when evaluating the practical utility of PRS.
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