Central corneal thickness and intraocular pressure before the intravitreal administration of ranibizumab and in the early period following the injection.

The aim of the study was to determine the differences in the central corneal thickness and intraocular pressure measured before intravitreal administration of ranibizumab and at 30 to 60 minutes after the injection. The intraocular pressure was analysed as a stand-alone parametre and in correlation with the central corneal thickness. 72 patients (144 eyes) were enrolled. The treated eyes were compared to the fellow, non-treated eyes. The mean central corneal thickness in a treated eye was 558 /Im and 596,μm at baseline (before the injection) and after the injection, respectively (p< 0.05). The mean intraocular pressure not correlated to the central corneal thickness in a treated eye 15.29 mmHg and 16.83 mmHg at baseline and post-injection, respectively (p< 0.05). When assessed in correlation with the central corneal thickness, the intraocular pressure did not increase post-injection in the treated eyes.