Optimizing myocardial cell protection with xanthine derivative KMUP-3 potentiates autophagy through the PI3K/Akt/eNOS axis.

Shang-En HuangJong-Hau HsuBo-Wen ShiauYi-Ching LiuBin-Nan WuZen-Kong DaiChung-Pin LiuJwu-Lai Yeh

Published in: Basic & clinical pharmacology & toxicology (2024)

These findings enable the core pathway of PI3K/Akt/eNOS axis in KMUP-3-enhanced autophagy activation and suggest its principal role in safeguarding against cardiotoxicity.

Keyphrases

pi k akt
signaling pathway
cell cycle arrest
cell death
endoplasmic reticulum stress
cell proliferation
single cell
oxidative stress
cell therapy
heart failure
stem cells
endothelial cells
metabolic syndrome
bone marrow
water soluble