Login / Signup

CircZNF609 as a prototype to elucidate the biological function of circRNA-mRNA interactions.

Manuel BeltranFrancesca RossiIrene Bozzoni
Published in: Molecular & cellular oncology (2022)
Circular RNAs (circRNAs) are expressed and are regulated in many biological processes but little is known about their ability to directly control mRNA homeostasis. We show that circRNA zinc finger protein 609 (circZNF609) interacts with several mRNAs increasing the final protein levels, which in the case of the cytoskeleton-associated protein 5 (CKAP5) leads to a stabilized microtubule cytoskeleton and an enhanced tumor cell proliferation.
Keyphrases
  • binding protein
  • cell proliferation
  • protein protein
  • amino acid
  • transcription factor
  • small molecule
  • cell cycle