Rare germline mutations in African American men diagnosed with early-onset prostate cancer.

Jennifer L Beebe-DimmerKimberly A ZuhlkeAnna M JohnsonDaniel LiesmanKathleen A Cooney

Published in: The Prostate (2018)

Protein-truncating mutations in BRCA2 and BRIP1 were discovered in African American men diagnosed with early-onset prostate cancer. Further study is necessary to determine the role of rare, missense variants to prostate cancer incidence, and progression in this group of high-risk men.

Keyphrases

early onset
african american
prostate cancer
radical prostatectomy
late onset
middle aged
risk factors
copy number
autism spectrum disorder
dna repair
protein protein
amino acid